Bausch + Lomb: Biotrue™ Multi-purpose Solution

Biotrue™ utilizes hyaluronan a lubricant found in the eyes

Eye's natural lubricant

Biotrue™ hydrates contact lenses in a way that eyes stay hydrated – by utilizing hyaluronan (HA), a lubricant found throughout the body, including tears1 and the corneal epithelium2.

HA has many benefits for the eyes:

  • It forms a free-flowing network on the lens surface – attracting water to envelop lenses in a moisture-rich cushion.
  • It helps stabilize tear film and reduce friction2.
84% of patients say Biotrue™ provides continuous comfort.

Hyaluronan: A Review of Its Properties, Ophthalmic Uses and Research

Hyaluronan, which is found throughout the body, may have a protective effect against oxidative damage to cells.

By Marjorie Rah, OD, PhD

Many scientists and engineers have discovered that rather than attempting to recreate the wheel to develop a new tool, it is easier, and often more efficient, to simply improve upon products or systems that already exist. Often, nature is the inspiration for these innovative ideas. For instance, nocturnal helmet geckos have been found to have excellent night vision due to a series of distinct concentric zones of different refractive powers.

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1 Frescura M, Berry M, Corfield A, Carrington S, Easty D. Evidence of hyaluronan in human tears and secretions of conjunctival cultures. Biochem Soc Trans 1994;22:228S.

2 Lerner L, Schwartz D, Hwang D, Howes E, Stern R. Hyaluronan and CD44 in the human cornea and limbal conjunctiva: letter to the editor. Exp Eye Res 1998;67:481-4.

3 Results from a clinical trial in which a total of 291 subjects were enrolled wearing a range of marketed soft contact lenses and using various soft contact lens care products. Subjects were dispensed Biotrue™ and participated in a CAWI (Computer Aided Web Interviewing) between day 7 and day 11 of the clinical trial. Subject responses were measured using a six-point Likert Scale in which 1 = strongly disagree and 6 = strongly agree. Results represent reported percentage agreement ratings.

4 Results of in vitro study performed to evaluate the rate of release of sodium hyaluronan (HA) from both traditional hydrogel (Bausch + Lomb SofLens®38 contact lenses, SofLens for Astigmatism lenses, and Vistakon ACUVUE 2) and silicone hydrogel contact lenses (Bausch + Lomb PureVision® contact lenses, Vistakon ACUVUE Oasys, Vistakon ACUVUE Advance, CIBA O 2OPTIX, CIBA Night & Day, and CooperVision Biofinity) over a 20-hour time period. Lenses were placed in Bausch + Lomb standard lenses cases and soaked overnight in Biotrue™ prepared with HA tagged with fluorescein. Hank’s balanced salt solution (HBSS) was dripped over the lenses at a rate that approximates tear film secretion in the human eye as determined by Reddy I, et al. Ocular Therapeutics and Drug Delivery. Technomic Publishing Co. 1996; 174. The solution that rinsed off the lenses was collected hourly over a 20-hour period and the fluorescence intensity was detected. A standard curve was used to determine the concentration of fluorescein-tagged HA present in each rinse solution. The extended presence of fluorescein-tagged HA in the rinse solutions indicates the percent of HA retained on the lens surface.

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